Focal adhesions as mechanosensors: The two-spring model
نویسندگان
چکیده
منابع مشابه
Focal adhesions as mechanosensors: the two-spring model.
Adhesion-dependent cells actively sense the mechanical properties of their environment through mechanotransductory processes at focal adhesions, which are integrin-based contacts connecting the extracellular matrix to the cytoskeleton. Here we present first steps towards a quantitative understanding of focal adhesions as mechanosensors. It has been shown experimentally that high levels of force...
متن کاملFocal adhesions as mechanosensors: a physical mechanism.
Focal adhesions (FA) are large, multiprotein complexes that provide a mechanical link between the cytoskeletal contractile machinery and the extracellular matrix. FA exhibit mechanosensitive properties; they self-assemble and elongate upon application of pulling forces and dissociate when these forces are decreased. We propose a thermodynamic model for the mechanosensitivity of FA, according to...
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The transition of cell-matrix adhesions from the initial punctate focal complexes into the mature elongated form, known as focal contacts, requires GTPase Rho activity. In particular, activation of myosin II-driven contractility by a Rho target known as Rho-associated kinase (ROCK) was shown to be essential for focal contact formation. To dissect the mechanism of Rho-dependent induction of foca...
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What are they? Focal adhesions are the anchor points of the cell. These dynamic cytoskeletal structures are regions where the cell membrane firmly attaches to the extracellular matrix or the substratum. At the same time, focal adhesions provide scaffolding; they associate with an elaborate actin network inside the cell. Importantly, it’s now known that focal adhesions also act as communication ...
متن کاملMechanotransduction and focal adhesions.
Cellular FAs (focal adhesions) respond to internal and external mechanical stresses which make them prime candidates for mechanotransduction. Recent observations showed that the FA proteins including vinculin, FAK (FA kinase) and p130Cas are crucial for the ability of cells to transmit forces and to generate cytoskeletal tension. When mechanically stimulated, cells respond by modulating the spr...
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ژورنال
عنوان ژورنال: Biosystems
سال: 2006
ISSN: 0303-2647
DOI: 10.1016/j.biosystems.2005.05.019